Dr. Kintur Sanghvi has been an avid researcher and served as Primary investigator or Co-investigator for multiple landmark clinical trials (described below) exploring new treatment options. He is currently actively investigating alternate treatment for Hypertension. If you are suffering from Hypertension and interested in exploring alternate treatment clinical trial, you can click on the link below.
Research Trials:
- TARGATE BP (PI) Ablative solution, renal denervation using chemical ablation
- RADIANCE II (PI) study of the ReCor Medical Paradise System to evaluate Renal Denervation in Clinical Hypertension
- ACURATE NEO (PI) IDE trail of the new Acurate Neo Transcatheter Aortic Valve.
- Onyx ONE (PI) One Month DAPT study with Resolute ONYX DES
- SAFE –STEMI for seniors. (PI)
- SCOR-FLEX NC (PI) scoring NC balloon in coronary disease trial.
- ECLIPSE (PI) Orbital atherectomy before DES for severely calcified coronary lesions
- DEFINE PCI (PI) Physiologic assessment of coronary stenosis following PCI
- REDUCE COBRA (PI): Randomized trial of Cobra PzF Stenting to Reduce Duration of Triple Therapy
- CROSS BOSS First (PI) Randomized Comparison of a CrossBoss First vs. Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion
- RADIANCE HTN (PI) study of the ReCor Medical Paradise System to evaluate Renal Denervation in Clinical Hypertension
- ROCC Study ((PI) Rotational vs. Orbital coronary atherectomy study
- Radial Hemostasis Study ((PI) Randomized comparison of TR vs. Safe Guard band
- SYMPLICITY HTN- 4 (PI) Renal Denervation for moderate HTN
- EnligHTN (PI) Renal Denervation for severe resistant HTN
- Regulate PCI (PI)
- OPEN (Sub I) Evaluation of Safety and Efficacy of the FlexStent Femoropopliteal Self-Expanding Stent System Study
- ADVICE II (PI) coronary physiology validation of iFR
- SIMPLICITY HTN -3 (PI) Renal Denervation in Patients with Uncontrolled Hypertension
- COBRA: cobra pzf™ coronary stent system in native coronary arteries for early healing, thrombus inhibition, endothelialization and avoiding long-term dual anti-platelet therapy. the pzf™ shield trial
- LUCY: (Co-PI) TriVascular Evaluation of FemaLes who are Underrepresented Candidates for Abdominal Aortic AneurYsm Repair
- VPA AMPLATZER: (Co-PI) Closure of Muscular Ventricular Septal Defects with the AMPLATZER™ Muscular VSD Occluder: Post-Approval Study
- SHIELD: (Co-PI) Supporting Patients Undergoing HIgh-Risk PCI Using a High-Flow PErcutaneous Left Ventricular Support Device (SHIELD II)
- CHOCOLATE TOUCH: A Randomized Trial to confirm the Safety and Effectiveness of Chocolate Touch™ Paclitaxel Coated PTA Balloon Catheter, in Above the Knee Lesions
- LEVANT 2 (SubI) Continuation Registry of the MOXT Drug Coated Balloon for Treatment of Femoropopliteal Arteries: Continued Access Registry
- GREECE: Global Revascularization and Evaluation of Excimer Laser in The Coronaries: GREECE II
- DURABILITY: The US StuDy for EvalUating EndovasculaR TreAtments of Lesions in the Superficial Femoral Artery and Proximal Popliteal By usIng the Protégé EverfLex NitInol STent System Post Approval Study
- ILLUMENATE: Prospective, Randomized, Multi-Centered, Single-Blind Study for the Treatment of Subjects Presenting with De Novo Occluded/Stenotic or Re-occluded/Restenotic Lesions of the Superficial Femoral or Popliteal Arteries using a Paclitaxel-Coated or Bare Percutaneous Transluminal Angioplasty Balloon Catheter
- VISION: EValuatIon of the PantheriS OptIcal COherence Tomography ImagiNg Atherectomy System for use in the Peripheral Vasculature
- DANCE-POP: Delivery of Dexamethasone to the Adventitia to eNhance Clinical Efficacy after POPliteal Artery Revascularization
- ABLATE: Atherectomy By Laser Ablation with Turbo-Elite
- LUTONIX BTK: A Prospective Multicenter, Single Blind, Randomized, Controlled Trial Comparing the Lutonix Drug Coated Balloon vs Standard Angioplasty for Treatment of Below the knee (BTK) Arteries
- InPACT (SubI) A Randomized Trial of the Medtronic – Invatec IN-PACT Admiral Drug-Eluting Balloon vs Standard Percutaneous Transluminal Angioplasty (PTA) for the Treatment of Atherosclerotic Lesions in the Superficial Femoral and/or Proximal Popliteal (SFA/PPA)
- EVOLVE II(SubI) A Prospective Multicenter Trial to Assess the Safety and Effectiveness of the SYNERGY Everolimus-Eluting System for the Treatment of Atherosclerotic Lesions
- PARACHUTE (Co-PI) Percutaneous Ventricular Restoration in Chronic Heart Failure EXCITE ISR (Co-PI) LASER for in-stent restenosis SFA
- VISIBILITY (Co-PI) Deborah Heart & Lung ctr)
- PROMISE (Sub I) Deborah Heart & Lung ctr)
- EVOLVE (Sub-I)
- TRIOLOGY ACS (Clarks Summit, PA)
- PREVENT HIV HEART (PI) Can Peroxisome Proliferator Activating Receptor-γ Agonists Thiazolidinediones Reverse the Endothelial Dysfunction in Human Immunodeficiency Virus infected patients being treated with Highly Active Antiretroviral Therapy
- Radial vs. Femoral in AMI: Effect of experience
- Other multicenter trial experience: ARRIVE, ARRIVE II, Apex AMI, PERISCOPE, ACUITY CRUSADE, RIPER, C-PORT
Abstracts Presented:
- EUROPCR 2020: Renal artery variations in patients with essential hypertension from the RADIANCE-HTN SOLO trial.
- TCT 2019: Evaluation of Railway Sheathless Access System For Transradial Coronary And Peripheral Intervention.
- EUROPCR 2019: The use of social media to recruit study participants for a multicenter, randomized, sham-controlled trial for hypertension: Insights from the RADIANCE-HTN SOLO trial
- ACC 2019: Ultrasound evaluation of the diameter of Pedal Arteries in patients with high prevalence of peripheral arterial disease: Pedal First
- ACC 2019: Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicenter, international, single-blind, randomized, sham-controlled trial. Six months follow-up results
- TCT 2018: Predictors of successful Renal Denervation: Multivariate analysis of RADIANCE-HTN SOLO cohort.
- EURO PCR 2018: Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicenter, international, single-blind, randomized, sham-controlled trial. LANCET. E Published May 23 2018.
- CRT 2018: Radial Hemostasis Study: A Randomized Comparison of Safeguard Radial And TR Band On Radial Artery Occlusion
- CRT 2018: Predictors Of Procedural Complication During Rotational Atherectomy vs Orbital Atherectomy in Calcified Coronary Artery Disease: A Contemporary Retrospective Comparative Analysis (ROCC study)
- ACC 2018: Trends in Usage and Clinical Outcomes of Coronary Atherectomy for the Treatment of Severe Coronary Artery Disease: A Report from the NCDR (National Cardiovascular Data Registry) CathPCI Registry.
- Nirat Beohar, MD, Andres M. Pineda, MD, Sunil V. Rao, MD, Jeffrey Moses, MD, James Blankenship, MD, Kintur A. Sanghvi, MD, Martin B. Leon, MD, Gregg W. Stone, MD, Ajay J. Kirtane, MD, SM
- TCT 2017: Late Breaking trial: Cross Boss First trial investigators: Randomized Comparison of a CrossBoss First vs. Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusions: the “CrossBoss First” trial.
- TCT 2017: Kintur Sanghvi, Joe Kusick, Courtney Walsh. Retrograde Tibio-Pedal Access For Revascularization Of Lower Extremity Peripheral Artery Disease Using 6 Fr Slender Sheath: The “Pedal First” Pilot Project
- TCT 2016: Allen McGrew, Kintur Sanghvi. Rotational Atherectomy vs Orbital Atherectomy in Calcified Coronary Artery Disease: A Contemporary Retrospective Comparative Analysis (ROCC study).
- SCAI 2016: Kintur Sanghvi, Jeff Stahl, Allen, Richard Kovach. Transradial Aortic Paravalvular Leak Closure.
- SCAI 2016: Nha Huynh, Kintur Sanghvi et.al. Effect Of Hemostatic Device On Radial Artery Occlusion: A Randomized Comparison of Safeguard Radial and TR Band
- CRT2016: Kintur Sanghvi, Thomas Morris, Richard Kovach. Optimal Aorto-ostial Lesion Treatment with Flash Ostial Balloon Is Feasible and Safe.
- SCAI 2013: Kintur Sanghvi, Samir Pancholy. Hemodynamic Assessment Of Severe Aortic Stenosis Via Transradial Approach Is Feasible.
- AIM RADIAL 2012: Harit Desai, Kintur Sanghvi. Transradial Laser Atherectomy to Revascularize Complex Coronary Artery Disease
- SCAI 2007: Kintur Sanghvi, Tejas Patel, Cezar Staniloae et.al. Histopathologic changes of the radial artery secondary to transradial catheterization. Implications for its use as a coronary artery bypass surgery conduit (One of the top ten abstracts)
- SCAI 2007: Kintur Sanghvi, Ravi Srinivas, John Coppola, Cezar Staniloae. Improvement in Creatinine clearance in diabetic patients after percutaneous renal artery angioplasty and stenting
- SCAI 2005: Kintur Sanghvi, John Coppola, Cezar Staniloae, Tejas Patel. Can Nitric Oxide Donor Decrease the incidence of Radial Spasm During The Transradial Intervention? Radial Cocktail Study
- Kamkura Live 2000:“Direct Stenting- Indian Experience.” Asian Pacific Interventional Cardiology Conference. April 13, 2000. Kamakura. Japan
- “Stent - Deployment Strategy.” Coronary Intervention-2000. South East Asian cardiology meeting, September 2000 at Nairobi, Kenya